The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity

weight

Time frame · Baseline, the end of Week 12 and the end of Week 24

To analysis whether weight shows any significant trend with time changes.

Concentration of blood glucose in blood

Time frame · Baseline, the end of Week 12 and the end of Week 24

To analysis whether concentration of blood glucose in blood show any significant trend with time changes.

Concentration of total cholesterol in blood

Time frame · Baseline, the end of Week 12 and the end of Week 24

To analysis whether concentration of total cholesterol in blood show any significant trend with time changes.

Concentration of high density lipoprotein in blood

Time frame · Baseline, the end of Week 12 and the end of Week 24

To analysis whether concentration of high density lipoprotein in blood show any significant trend with time changes.

Concentration of low density lipoprotein in blood

Time frame · Baseline, the end of Week 12 and the end of Week 24

To analysis whether concentration of low density lipoprotein in blood show any significant trend with time changes.

Concentration of triglyceride in blood

Time frame · Baseline, the end of Week 12 and the end of Week 24

To analysis whether concentration of triglyceride in blood show any significant trend with time changes.

CBCT test results

Time frame · Baseline, the end of Week 12 and the end of Week 24

CBCT is a tool to measure cognitive function. It includes 4 dimensions: wire test, symbol encoding, continuous operation, and digital breadth.The wired test reflects the dimension of the speed of patient information processing. Symbolic coding reflects the patient's information processing speed, attention, working memory, reasoning, and problem-solving dimensions. Continuous manipulation reflects the patient's attention Dimension. The numerical breadth reflects the patient's working memory dimension.The basic information of the completion of each assessment and the completion of each assessment are calculated by the Chinese population norm model T-score, Deficit value, and extent and dimension of damage. Reflected in each assessment and the percentiles of neurocognitive function in the Chinese population.

17-item Hamilton Depression Rating Scale (HAM-D17) Score

Time frame · Time Frame: Baseline, the end of Week 2, 4， 8，12，16 and 24

HAM-D17 has been the gold standard for the assessment of depression. The score needs to be based on clinical interviews, and the time frame of the assessment is usually the situation in the previous week. Most items use a 5-point scale of 0 to 4. The standard of each level is: 0 indicates none, 1 indicates mild, 2 indicates moderate, 3 indicates severe, and 4 indicates extremely severe. A few items adopt the 3-level scoring method with 0\~2 points, and the grading standard is: 0 indicates none, 1 indicates mild to moderate and 2 indicates severe.

Treatment Emergent Symptom Scale (TESS) Score

Time frame · Time Frame: Baseline, the end of Week 2, 4， 8，12，16 and 24

Treatment Emergent Symptom Scale was developed by The National Institute of Mental Health (NIMH) in the USA in 1973. It is a safety assessment tool after treatment of psychiatric diseases. Evaluation is based on patient reports, physical examination results, and laboratory reports, and some items should also be consulted with the patient's family. Severity item is scored from 0 (not present) to 4 (severe). Higher scores represent a more severe condition.